Buy 4'-Bromovalerophenone | 7295-44-5

Contact us to discuss your requirements of 2-bromovalerophenone. Our experienced sales team can help you identify the options that best suit your needs.

Synthesis Analysis

The synthesis of 4'-bromovalerophenone and its derivatives involves multiple steps, including bromination, chlorination, acylation, and catalytic reactions. For instance, bromo-2′,4′-dichloroacetophenone, a related compound, is synthesized from glacial acetic acid and m-dichlorobenzene, indicating the versatility of bromination techniques in producing various brominated phenones (Yang Feng-ke, 2004). α-Bromo-4-hydroxyacetophenone synthesis further illustrates the critical role of catalytic bromization, showcasing the chemical's adaptability in synthesis processes (Han Qing-rong & Tang Rong-ping, 2006).

Molecular Structure Analysis

The molecular structure of bromovalerophenone derivatives is characterized using various spectroscopic techniques, including NMR and IR spectra, to confirm their chemical structures. The detailed analysis of these compounds reveals the intricate molecular frameworks that these brominated phenones possess, which are crucial for their chemical reactivity and properties (Deng Ji-hua, 2008).

Chemical Reactions and Properties

Bromovalerophenone compounds participate in a range of chemical reactions, including photoinduced cleavage of DNA, demonstrating their potential as photoinducible DNA cleaving agents. These reactions underscore the chemical's utility in biochemistry and molecular biology, with specific derivatives showing sequence selectivity in DNA interactions (P. Wender & R. Jeon, 1999).

Check Digit Verification of cas no The CAS Registry Mumber 49851-31-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,8,5 and 1 respectively; the second part has 2 digits, 3 and 1 respectively. Calculate Digit Verification of CAS Registry Number 49851-31: (7*4)+(6*9)+(5*8)+(4*5)+(3*1)+(2*3)+(1*1)=152 152 % 10 = 2 So 49851-31-2 is a valid CAS Registry Number.

For more information, please visit bromazolam onset.

49851-31-2

Relevant articles and documents

Enantioconvergent Cu-Catalyzed Radical C-N Coupling of Racemic Secondary Alkyl Halides to Access α-Chiral Primary Amines

Cheng, Jiang-Tao,Dong, Xiao-Yang,Gu, Qiang-Shuai,Li, Zhong-Liang,Liu, Juan,Liu, Xin-Yuan,Luan, Cheng,Wang, Fu-Li,Wang, Li-Lei,Yang, Ning-Yuan,Zhang, Yu-Feng

supporting information, p. 15413 - 15419 (2021/09/30)

α-Chiral alkyl primary amines are virtually universal synthetic precursors for all other α-chiral N-containing compounds ubiquitous in biological, pharmaceutical, and material sciences. The enantioselective amination of common alkyl halides with ammonia is appealing for potential rapid access to α-chiral primary amines, but has hitherto remained rare due to the multifaceted difficulties in using ammonia and the underdeveloped C(sp3)-N coupling. Here we demonstrate sulfoximines as excellent ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides (>60 examples) by copper catalysis under mild thermal conditions. The reaction efficiently provides highly enantioenrichedN-alkyl sulfoximines (up to 99% yield and >99% ee) featuring secondary benzyl, propargyl, α-carbonyl alkyl, and α-cyano alkyl stereocenters. In addition, we have converted the masked α-chiral primary amines thus obtained to various synthetic building blocks, ligands, and drugs possessing α-chiral N-functionalities, such as carbamate, carboxylamide, secondary and tertiary amine, and oxazoline, with commonly seen α-substitution patterns. These results shine light on the potential of enantioconvergent radical cross-coupling as a general chiral carbon-heteroatom formation strategy.

Synthesis of α,β-dibromo ketones by photolysis of α-bromo ketones with N-bromosuccinimide: Photoinduced β-bromination of α-bromo ketones

Moon, Da Yoon,An, Sejin,Park, Bong Ser

, (2019/10/28)

Irradiation of α-bromopropiophenones in the presence of NBS results in the formation of α,β-dibromopropiophenones, which can be viewed as β-bromination of α-bromopropiophenones. The reaction is believed to go through a series of reactions; photoinduced C–Br bond cleavage, elimination of HBr to give α,β-unsaturated ketone intermediates, and addition of Br2, which are formed by the reaction between HBr and NBS. From mechanistic studies of the reaction, we have also found a very convenient method for α-debromination of the α,β-dibromopropiophenones which is by simple irradiation of the dibromo ketones in acetone or 2-propanol without the use of any additives. Our results demonstrate that bromine can be added into or eliminated from the alpha, beta, or both positions to the carbonyl group by photochemical methods, which make synthetic options of bromine containing carbonyl compounds versatile.

Preparation method of alpha-bromo aromatic ketone compounds

-

Paragraph 0016, (2018/07/30)

The invention discloses a high-efficiency and green preparation method of alpha-bromo aromatic ketone compounds. The preparation method comprises that under a certain temperature, alpha-H of aromaticketone compounds is brominated to prepare the alpha-bromo aromatic ketone compounds in an acidic medium with hydrogen peroxide as an oxidant and an inorganic bromide as a bromine source under the condition of an alcoholic solvent or solvent-free. The main features of the method are that bromination reagents such as bromine, bromine dioxane, 2,4,4,6-tetrabromocycloketone, perbrominated quaternary ammonium salts, C5H5N.HBr.Br, NBS, dibromohydantoin, copper bromide and cuprous bromide are not used as the bromine source, so that production cost is reduced, and environmental pollution caused by heavy metal bromination reagents is avoided; and in addition, the method uses hydrogen peroxide and inorganic bromide reagents to prepare the alpha-bromo aromatic ketone compounds in situ, the reaction conditions are mild, the experimental operation is simple, the selectivity is good, and the product is single, and therefore, the preparation method has very high applicability and universality, and has a very broad application prospect.

Are you interested in learning more about a-bromovalerophenone? Contact us today to secure an expert consultation!