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Best Nootropics in | How the Top 8 Brands Compare
Nootropics, also known as smart drugs or cognitive enhancers, have been around since the late s but have exploded in mainstream popularity during the last decade. The nootropic market hit $10.7 million in and is projected to double that figure in the next three years.1 Its easy to get excited about something that could erase so many of our day-to-day productivity problems brain fog, short attention spans, and fading memories, to name a few but our brains needs are all unique. And sifting through dozens of supplements that all make the same claims to find the right choice for you is a Herculean task.
We researched, investigated, tried, and compared the most compelling nootropic options of to help you find the right smart pill for your needs. If youre short on time, here is the rundown of our top picks.
Our Top Choice
ThesisThesis is our top nootropic recommendation. Their formulas are scientifically backed and stimulant-free.
Thesis supplements help rebalance the brain, without negative habit forming side effects. Choose between 5 personalized brands to enhance your mental performance.
Shop on Thesis and take 10% off your first order with code INNERBODY.
Table of Contents
In this Review
Why you should trust us
Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles. As nootropics have emerged and proliferated in the supplement landscape, weve invested serious time to determine which are worth your consideration.
Weve spent hundreds of hours researching and testing various nootropics, including specialized formulas, generalized nootropics, and individual ingredients. Over the course of our nootropic studies, weve read over 350 clinical studies examining the safety and efficacy of various nootropic ingredients. To get a first-hand look and feel, we ordered and tested nootropic supplements ourselves, meaning were speaking from experience not just regurgitating what others have said.
Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy. To keep things up to date, we monitor the nootropics landscape and update this page as information changes.
How we evaluated nootropics
Nootropics are complicated supplements, but that doesnt mean its impossible for the average person to understand them. When we review nootropic supplements, we consider four main criteria:
- How well they work
- How safe they are and what precautions the manufacturers take
- How much they cost
- How convenient they are to purchase and use
Typically, a nootropics effectiveness is the most important criterion: no matter how good of a deal it is or how safe it may be, it doesnt make sense to invest in a product that just doesnt work. Safety ranks second above cost; your brain is a delicate organ, and many nootropics contain ingredients without a long history of adequate research, which calls their safety into question far more than something like a multivitamin. Those ingredients and a companys testing routine vary much more dramatically than cost or convenience.
Thesis comes close to a clean sweep in our ratings in , winning in effectiveness and convenience (with TruBrain as a close runner-up) and matching Mind Lab Pro in safety. Its one of the most effective nootropics out there, with:
- Rigorous safety standards
- Research-backed ingredient lists that are well-dosed (which is astonishingly rare in the nootropic landscape)
- Lots of little conveniences that add up, like packets with each days serving so you dont have to count pills
- Free one-on-one consultations to help you maximize the benefits you can get
The only area where Thesis falls short is its price: spending $79 or more per month on a nootropic is out of reach for many of us. If you have a tighter budget, Focus Factor has the most reasonable price point on our list by a long shot; it costs four times less per dose than our second least expensive nootropic, Hunter Focus.
Effectiveness
Winner: Thesis
An effective nootropic is one that makes a big difference in your mental state without overloading your system with thousands of unnecessary milligrams of botanicals, vitamins, minerals, and other ingredients. If 100mg works similarly to 10,000mg, its going to be much more effective to get 100mg in a blend. And when it comes to nootropics, effectiveness becomes slightly more complicated because there are two major categories:
- Generalized nootropics, which claim to increase memory and focus, reverse brain aging, and regulate mood all in one dose
- Specialized nootropics, which sink all of their focus into one area
Because of their jack-of-all-trade tendencies, generalized nootropics tend to be less effective than specialized nootropics.
We think Thesis is the most effective nootropic because of its reasonable dosing and, more importantly, its unique blend configuration. Where most other nootropics provide one formula, Thesis lets you try four of its six formulas in a Trial Kit before committing to your favorite (or favorites). Each blend is dedicated to a specific part of your cognition you might want to enhance, such as motivation and creativity, so you can utilize effective ingredients to treat the aspect of your cognitive health thats most important to you.
Here's a short video showing the sort of package you'll receive in the mail if you order from Thesis, as well as sharing summary details about its effectiveness from our team who tested it:
TruBrains drinkable nootropics take a similar approach but are ultimately less effective because not every formula has the same scientific robustness as all of Thesis, and the drinkable liquid means there are more ingredients necessary for a good flavor like agave syrup, xylitol, citric acid, and cane sugar that you just wont see in a capsule nootropic like Thesis.
Safety
Winner: Thesis
Runner-up: Mind Lab Pro
Despite having been around since the mid-s in some form, nootropics still often use lots of ingredients without much research that backs up positive effects on cognition. Because your brain is a sensitive and delicate organ that controls every part of your life, its critical that nootropic supplements are safe. The more research into a product or ingredient has behind it, the more we know about its safety and can make better-informed decisions. We consider the following factors to be critical for our safety scores:
- Clarity around ingredient lists (not hiding dosing information in proprietary blends)
- Transparent testing and manufacturing conditions
- Clear instructions on necessary tasks like cycling
Both Thesis and Mind Lab Pro are exceptionally safe nootropic supplements. Neither contains hazardous ingredients youd need to cycle (though Thesis still recommends taking at least one day off a week from their nootropics, just in case), and both use ingredients that are backed by the latest research.
Both Mind Lab Pro and Thesis make their nootropics in GMP-certified, FDA-registered facilities, but Thesis is more transparent about its use of third-party testing for ingredient and formula purity. And more importantly, Thesis uses short lists of ingredients in doses that are closely aligned with scientific studies. Mind Lab Pro is mostly underdosed (only three ingredients are present at the same doses found in clinical studies), though their in-house study found the nootropic had great success matching, if not exceeding, said studies.
Cost
Winner: Focus Factor
New technologies and supplements are often much more expensive than ones that are simpler or have been around for longer. For the most part, nootropics follow this trend. Prices can range considerably depending on the manufacturer, ingredient list, and other factors but generally fit into one of two categories:
- $35 or below and lower quality
- $65 or above and higher quality
Among the group of nootropics that provide a reasonable formula, Focus Factor is our least expensive nootropic by a long shot. The company makes several different nootropic supplements, and its Original formula is one of the best and the least expensive per serving on our list. One 15-serving bottle costs $14.99, and costs per dose decrease as you buy bigger bottles. Even the next least expensive nootropic, Onnits Alpha BRAIN, costs more than twice as much per serving.
While some of the biggest nootropic companies make one product and others make dozens, heres a breakdown of the costs and money-saving opportunities for our top picks most popular product in as close to a 30-day supply as possible. (All costs noted are pre-savings.)
Thesis
Mind Lab Pro
BrainMD Brain & Body Power MAX
TruBrain Personalized Drinks
Focus Factor Original
Alpha BRAIN Original
Hunter Focus
Qualia Mind
Cost
$119
$69
$146
$35
$22
$35
$72
$139
Number of servings
24
30
30
10
37
15
30
22
Cost per serving
$4.96
$2.30
$4.87
$3.50
$0.59
$2.33
$2.40
$6.31
Shipping?
Free on all orders
Free for 4-month supplies, variable otherwise
Free over $75, $7.95 otherwise
Free over $55, otherwise $9.99
Free over $50, $6.95 otherwise
Free over $150, variable otherwise
Free for 2+ bottles, $7.95 otherwise
$7.98-$12.98
Subscription or bulk deals?
Subscription
Bulk
Subscription
Both
Both
Subscription
Bulk
Subscription
Return policy
30 days
14 days
60 days
7 days
Not accepted
90 days
30 days
100 days
Focus Factor doesnt accept returns, which is a pain, but you can get both bulk deals and savings from subscription programs on your orders, which drops the price further. And it has the least expensive shipping across all of our favorite nootropic options, so while you cant get it in stores yet, you can get it regularly shipped to your front door for very little.
Convenience
Winner: Thesis
Runner-up: TruBrain
Nootropics arent the most convenient supplements. Most of the time, they require taking several medium-to-large pills with food in the morning. Depending on their ingredients, some will ask you to cycle your use. Cycling means that you take a few days, weeks, or months off to keep yourself from developing a tolerance or building up too much of a substance that could harm you in high enough doses. And while nootropics hopefully improve your memory enough to remember when you need a refill, subscription services that are easy to modify or cancel improve a nootropics convenience score.
Every formula from Thesis contains multiple capsules, which is a little inconvenient but standard for nootropics. However, its serving sizes are small for nootropics, and the company lets you opt in or out of a caffeinated formula whether or not youve purchased either form. Its caffeine pills come as a separate white capsule, so you can identify and skip it if youd rather not give up your morning coffee. Every days serving is packaged in an individual plastic bag, and while youll have to pull out a pair of scissors to open it (theres no tear notch), you wont have to count capsules and can easily slip the packet in your bag or pocket for on-the-go use.
Except for TruBrain, all other nootropics come in homogenous capsules or tablets in a big bottle, which means lots of counting and a commitment to either caffeinated or non-caffeinated formulas. Add in the excellent starter kit so you can try four of the six formulas before committing to your favorite few, and it becomes clear why we consider Thesis to be the most convenient nootropic.
On the other hand, you can take TruBrains six nootropic formulas in three different forms: liquid pouches (like squeezable applesauce), capsules, or powder sticks. It also offers a brain aging supplement with its own separate formula. This is the only liquid nootropic worth its salt right now, providing a convenient option for people who cant swallow pills. Like Thesis packets, its also easier to carry and take with you, and you wont have to worry about dividing up your daily dose.
How our top picks compare
Some of our favorite nootropic companies center on one formula. Others have broad horizons and create multiple lines of products. It can make trying to compare nootropic supplements confusing at best. To simplify things, weve created two charts:
- One comparing the companies themselves
- One comparing our favorite products from each brand
Heres a closer look at our top products from each company. This isnt an exhaustive list, and well go into more detail on a few other products from these same companies later, but this will give you a good starting point in your investigation.
Thesis
Mind Lab Pro
Brain MD Brain & Body Power Max
TruBrain Personalized Nootropic Drinks
Focus Factor Original
Onnit Alpha BRAIN
Hunter Focus
Neurohacker Collective
Cost
$119
$69
$146
$35
$22
$35
$90
$139
Number of servings per bottle
30
30
30
10
37
15
30
22
Cost per serving
$3.97
$2.30
$4.87
$3.50
$0.59
$2.33
$3
$6.32
Multiple sized bottles?
Form
Capsules
Capsules
Capsules
Liquid
Tablets
Capsules
Capsules
Capsules
Free trial?
Major allergens?
Soy (Logic blend only)
None
Fish, soy
Fish, soy
Soy, oat
Vegan?
Subject of scientific studies?
Here are a few important facts about the companies themselves:
Thesis
Mind Lab Pro
BrainMD
TruBrain
Focus Factor
Onnit
Hunter
Neurohacker Collective
Number of nootropic products
6 (1 form, 6 formulas)
1
63
19 (4 forms, 7 formulas)
18
4
1
1
FDA Good Manufacturing Processes (GMP or cGMP) certified facilities?
Product testing?
Third-party testing for purity
Testing ingredients for allergens, GMOs, microbes, pesticides, and herbicides; post-manufacturing testing for dissolution, disintegration, potency, purity, and activity (in-house and third-party)
Testing ingredients for identity, potency, and purity; testing post-manufacturing for ingredient verification, microbial contaminants, and heavy metals (in-house and third-party)
Third-party testing for purity and banned substances
Testing ingredients (form and potency), post-manufacturing testing for form, purity, and potential contaminants (in-house and by BSCG)
Subscription savings?
33%
15%
10%-50%
10%
15%
75% first order, 13% after
Bulk deals?
Shipping?
Free
Free for 2+ bottles, otherwise $9.95
Free for subscriptions and over $75, otherwise $7.95
Free
Free over $50, otherwise $6.95-$14.95
Free over $150, otherwise $7.65-$10.99
Free for 2+ bottles, otherwise $7.95
$7.98-$12.98
Return policy
30 days
60 days
60 days
7 days
Not allowed
90 days
30 days
100 days
What are nootropics, and how do they work?
Broadly speaking, nootropics are substances that improve your cognitive functioning. This definition is generous as it applies equally to supplements, prescription medication, and recreational drugs. In recent years, the supplement industry has grabbed onto this term to describe products with vitamins, minerals, amino acids, and botanicals that are designed to improve your brain game. Well follow suit and focus on nootropic supplements in this guide.
The first nootropic to use the term was a drug developed throughout the s and 60s called piracetam. It was intended to treat anxiety and provide patients with a soothing experience that might even lull them to sleep.2 The effect was quite different than what its creators intended, as users reported sharper focus, and later testing pointed toward improved memory. (At the time of writing, the FDA still hasnt approved piracetam for use in supplements or as a prescription medication, though many still take it.)3 Nootropics also include prescription medications like Adderall and Ritalin, as well as medications for dementia and Alzheimers disease. Caffeine is also a nootropic substance and an ingredient youll find in many nootropic supplements.
Nootropic supplements may have one ingredient, or they may have dozens. Some ingredient lists look similar to multivitamins, and others focus more on cutting-edge botanicals. Because no two brains are identical, the best nootropic for our team or other people may not work for you, but well provide all of the research and information you need to make the best decision in this guide.
Contemporary nootropics generally have three main goals:
- Protect your brain from damage
- Improve your memory, learning, and attention
- Regulate your mood
Not every nootropic does all three; some have a more specific focus, such as improving your learning ability or neuroprotection. These kinds of nootropics are called specialized nootropics. Others, called generalized nootropics, try to improve your brains function holistically across all three categories. But either way, all nootropics are designed to help your brain work more efficiently.
As cognitive enhancers, nootropic ingredients alter how your nerve cells and neurons work. This takes place in a variety of ways, including:
- Affecting circulation to the brain
- Positively impacting signaling pathways
- Combating oxidative stress
- Regenerating and strengthening neural connections
- Improving mitochondrial function
- Increasing the expression of neurotransmitters, like acetylcholine and dopamine
Common nootropic ingredients and studies of them
To better understand the potential mechanisms of action in any nootropic, we have to take a closer look at its ingredients. Unfortunately, there are several hundred ingredients used in these kinds of supplements, yet manufacturers claim that all of them work equally well. This, obviously, isnt true. A vast majority of nootropic ingredients have mixed evidence of their benefits and few research studies verifying these benefits.
That said, there are some nootropic ingredients that research supports wholeheartedly (or close to it). Here are nine of the best ingredients you should consider noteworthy when picking a nootropic supplement.
Choline
Choline is an essential nutrient that allows our bodies to make phosphatidylcholine, a fatty acid necessary to build our cell membranes. There are several choline-related ingredients you might find in a nootropic supplement, including choline, phosphatidylcholine, citicoline, and alpha-glycerophosphocholine (alpha-GPC). The latter two are the most common in nootropic supplements; between the two, citicoline works more effectively, but alpha-GPC is more common (though the research suggests that alpha-GPC may not produce statistically significant results over caffeine or a placebo).4 Citicoline more reliably improves episodic memory without serious side effects and is a contender for a future possible dementia or stroke treatment, though more research is necessary.5 6
Ashwagandha
Ashwagandha comes from a plant commonly used in Ayurvedic medicine to lower stress and anxiety levels, improve sleep, and regulate your HPA axis (which, for men, can also boost testosterone levels).7 In contemporary research, these practices hold up well, consistently lowering self-reported anxiety levels and improving sleep quality by up to 72%.8 9 By improving your sleep and lowering stress, ashwagandha seems to work as a natural nootropic, but theres some evidence it may also improve executive functioning in people with neurological and severe psychiatric disorders.10 Our testers noted significant drop-offs in their stress and anxiety levels when they tried ashwagandha supplements.
Tyrosine
Tyrosine is an amino acid commonly found in nootropic supplements because our bodies use it to create dopamine and norepinephrine. Having higher tyrosine levels means youll have more materials to make dopamine and norepinephrine, so your body is less likely to fall flat when you need them most. Studies show that higher tyrosine intake translates to better resilience in stressful or cognitively demanding situations, better short-term memory, and improved cognitive flexibility.11 12 Youre most likely to see tyrosine as NALT (N-acetyl L-tyrosine) in supplements.
Caffeine
You might find you dont function the same without your morning cup of coffee. Thats thanks to caffeine, a potent nootropic. While scientists dont know exactly how caffeine works in the brain, the running theory is that it prevents adenosine (which gradually makes you sleepy over the course of a day) from building up in your brain. This makes you feel more alert than you would be without caffeine. Repeatedly in scientific studies, caffeine improves human attention spans as much as prescription stimulants.13 A review also outlined how caffeine has neuroprotective effects against Alzheimers disease in animal models, though this still needs to be tested more rigorously in humans.14 And it doesnt take much caffeine to see these improvements even 100mg of caffeine, or what youd get from one cup of coffee, is enough to benefit your brain.
L-Theanine
Most common in tea leaves, theanine is another amino acid thats key for our relaxation. Like ashwagandha, its long been known to reduce stress, particularly when used in conjunction with caffeine (where theanine reduces the jittery effect so common when you have a little more than you need).15 Theres a link between L-theanine and improved sleep quality, too, though there still needs to be more research on this subject before anything can be stated definitively.16
Rhodiola rosea
Rhodiola rosea is an herb common in northern Europe thats similar to ashwagandha. Its surprisingly effective at reducing fatigue, calming your nerves, and lowering stress levels.17 Rhodiola also works in combination with tyrosine to improve your focus during stressful times.18 Theres some research on its role in learning and memory thats generally favorable, but most of these studies focus on animals, not humans.19
Bacopa monnieri extract
Bacopa monnieri is a botanical nootropic ingredient thats common for a good reason: its one of the better-studied nootropic ingredients and improves choline levels, giving ingredients like citicoline or alpha-GPC a boost. According to a meta-analysis, it seems to improve your attention and decrease reaction time.20 However, studies are mixed on whether or not bacopa extract improves memory recall, too.21
Ginseng
There are a few kinds of ginseng you might find, but they can generally be separated into Asian ginseng (including Korean red ginseng, a particularly potent form) and American ginseng. Generally, Asian ginseng improves cognitive performance more than American ginseng, though the American form does still have cognitive enhancement properties.22 It generally improves concentration, scanning ability, and memory recall and is thought to stabilize the nervous system and decrease neuroinflammation.23 Ginseng seems to be particularly potent when paired with ginkgo biloba, another nootropic botanical.24
Huperzine A
Huperzia serrata produces a potent compound known as huperzine A. Huperzine A raises your acetylcholine levels by limiting the amount of acetylcholinesterase (which breaks down acetylcholine) released. This essentially means youll have more acetylcholine available for synapses to take up for longer. It has potent antiepileptic and neuroprotective effects and, when used correctly, is perfectly safe.25 However, because nootropic supplements arent regulated by the FDA, theres a greater likelihood that supplements containing Huperzia serrata can be dangerous. When too much acetylcholine accumulates (known as cholinergic toxicity), you can experience things like headaches, nausea and vomiting, and confusion, and it can lead to overdose in extreme situations.
Its important to note that just because an ingredient works well in one research study, it doesnt mean the ingredient will work exactly like that in your body. Our brains are just as individual as our fingerprints, shaped by both genetics and our lived experiences. Everything from our weight and what we ate for breakfast to our parents reactions to medications can make individual nootropic ingredients interact differently from person to person. Likewise, these ingredients doses and interactions with other ingredients can change a lot about how they work. Some ingredients might keep others from working, while others might boost others ability to work. Most of this information hasnt been properly researched yet, so its hard to predict how a nootropic will work without an independent study of the product. (We take a look at the four studies that have been done on specific nootropic supplement formulas later in this guide.)
Keep an open mind while youre starting to try nootropics. We recommend starting with nootropics supplements that have relatively short ingredient lists so you can quickly pinpoint ingredients that do or dont work for you.
There are some other classes of ingredients that may not directly affect your brain like you might expect a classic nootropic to, but that are still important to support your brains overall health.
Amino acids
Like the rest of your body, your brain and central nervous system need amino acids to make proteins. Its well-known that the brain uses three amino acids tryptophan, tyrosine, and phenylalanine to make the three major neurotransmitters (serotonin, dopamine, and norepinephrine, respectively).26 But a study found seven amino acids that improved older adults cognitive, social, and psychological functioning: leucine, lysine, isoleucine, histidine, valine, phenylalanine, and tryptophan.27 The only amino acid that we know doesnt make much of a difference in your brain is glutamine. You might see some of these amino acids as acronyms like NALT (tyrosine), too.
Vitamins and minerals
Fatigue and brain fog are extremely common symptoms of vitamin and mineral deficiencies. B vitamins (especially B6, B9, and B12), vitamin D, iron, and magnesium are the most important vitamins and minerals for your cognitive health. Though direct analyses often yield mixed results, fatigue and brain fog make a big difference in how easily thoughts come to you and how good you feel, and vitamins and mineral deficiencies are more common than you might expect.28 Healing these deficiencies is often just as good as if not better than just taking a nootropic supplement.
Antioxidants
Oxidative stress is caused by a buildup of free radicals reactive oxygen species missing electrons that cause damage to nearby cells. It occurs due to aging, environmental pollution, exposure to tobacco smoke, food breakdown in our digestive system, and dozens of other small factors that add up over time. With enough buildup over time, oxidative stress can cause permanent damage and may lead to things like heart disease and cancer. This damage is most common and harmful in the brain due to its massive oxygen consumption and the fact that adult brains dont replace dead and dying cells.
Antioxidants have free electrons that they donate to the raving oxygen molecules, taming them and allowing the body to repair damage. There are thousands of antioxidant compounds, but things like omega-3 fatty acids, vitamins C and E, polyphenols, and carotenoids are potent antioxidants. Antioxidants are most useful when consumed alongside chemicals present in their natural forms like fruits, vegetables, and fish, but they can still help on their own in a supplement.
Insider Tip: You likely wont see pure amino acids in a nootropic supplement. Instead, youll see something with a letter before it, like L-theanine. This letter represents the direction the molecule is turned in production L- means its all turned to the left, D- means its all turned to the right, and DL- means theres some of both. L- amino acids are absorbed best by the body and are almost always cheaper.
Tolerance and habituation
Some ingredients require a little more care to use properly. Tolerance (our brains physically adapting to a new situation) and habituation (our psychological adaptations) can both be present while youre using nootropics. (These are both different from addictions, which involve an inability to control your use even when you want to and developing a dependence on it for daily functioning, among other features. It is possible to become addicted to some nootropics, though its not common.)
If a nootropic asks you to cycle, or occasionally take a few days off from taking it, its likely that it contains ingredients that could build a tolerance. These generally are ingredients that affect your brains acetylcholine levels, like huperzine A.
Ingredients to avoid
Some ingredients with little to no evidence still find their way into nootropic supplements. There arent many that are inherently dangerous; vinpocetine can induce miscarriages or birth defects if taken while pregnant, and huperzine A can cause acetylcholine toxicity if taken in extreme doses for too long. But plenty of ingredients are essentially filler. Sadly, most nootropics will contain at least one ingredient with questionable research behind it. Here are some of the worst offenders weve found, even in our favorite nootropics:
- Artichoke extract. Theres only one study (from ) on this topic. It suggests artichoke extract may reduce some biomarkers associated with Alzheimers disease, but theres no evidence it can otherwise support your brain.29
- Oat straw extract. Theres no clinical evidence this does anything for your brain.
- Dimethylaminoethanol (DMAE). This antioxidant was sold as an alternative to ADHD medication called Deanol between and , but it was recalled due to a lack of scientific evidence on its safety.30 There hasnt been much, if any, research on it since.
- Coleus forskohlii extract. This mint-like plant is advertised as being able to do a lot for an aging brain, but theres no evidence it has any cognitive benefits.
- Glutamine. Despite being the most common amino acid and protein building block in your body, it mostly works on rebuilding muscles post-workout unless youve experienced a lack of oxygen to the brain (and even that finding is tentative).31
- Taurine. Despite how frequently you might see it in energy drinks, and though taurine deficiencies are common in people with cognitive dysfunction, theres no clear evidence taking taurine improves cognition.32
Studies on our favorite nootropics
Because nootropic ingredients vary so wildly in their clinical support and almost no research studies look at ingredients in combination with each other, its always nice to see a company run a study on its product. There are some clear biases possible when a company funds a study, the researchers may feel pressured to produce certain results but some information is better than none.
Four of our top picks tested their nootropics in some capacity: Focus Factor Original, Alpha BRAIN, Mind Lab Pro, and Qualia Mind. In general, Mind Lab Pro worked the best on reaction time, anticipation, memory recall, and information processing (particularly among the 30-and-over crowd), and Focus Factor Original also had some significant positive findings on recall ability.33 34 Alpha BRAIN has two studies under its belt, both of which are somewhat mixed but suggest that it may improve verbal memory, and Qualia Minds findings were disappointing while participants reported significant improvements across six cognitive categories, they werent significant over a placebo.35 36 37 These findings ultimately make a big impact on how we judge these supplements, and while nothings going to work perfectly for every person, it provides insight as to the strengths and weaknesses of these products.
You can read more about these studies in the products full reviews, linked under each product breakdown in this guide.
Are nootropic pills safe?
No nootropic pills are created equally, so its hard to say theyre all safe. Many are safe for healthy adults who dont take any prescription medication, but that leaves out two-thirds of all U.S. adults, according to Georgetown Universitys Health Policy Institute.38 And nootropics can also interact with other supplements, so youll want to cross-check ingredient lists. As with any supplement, we encourage you to talk to your doctor before starting a nootropic to ensure it doesnt interfere with any conditions you have or medications you take.
Our top recommendations generally use ingredients in safe doses for most people. They err on the side of caution and are more likely to under-dose than overload your system with the latest and greatest botanicals, which is frustrating in practice but better for you in the long term. This isnt the case for every supplement well point out which ones to approach with extra caution in our product breakdowns but, in general, youre more likely to experience fewer effects than a laundry list of side effects.
Side effects and contraindications are always a possibility, though. Some ingredients cause more side effects than others. (Since many nootropics have at least 90mg of caffeine, we recommend curtailing your coffee and tea consumption until you know how this new energy source affects you.) Keep an eye out for things like headaches, stomach aches, and dizziness when youre starting a nootropic. If you find these symptoms dont go away after a day or two of use, stop using them and contact your doctor. It may be a poor ingredient fit, or nootropics might just not be a good idea for you.
Cycling
Some nootropics will require you to cycle (take days off in your weekly dosing routine). Its inconvenient and a bit of a pain to have to remember, but its important for your health to follow these instructions. Taking a few days off keeps them from building up in your brain, either flooding your body with excess acetylcholine that cant get cleaned up (and can cause problems like muscle twitching or decreased respiration) or causing you to develop a tolerance or dependency. Cycling requirements generally depend on a few ingredients notably huperzine A and other acetylcholinesterase blockers included in a given formula.
Other ingredients you might see that mean you should regularly take time off include:
- Caffeine
- Noopept
- Piracetam
- Modafinil
- N-acetyl cysteine (NAC)
Caffeine, for example, is an addictive stimulant (as you may know if you drink a cup of coffee each morning and dont feel right without it), whereas NAC regulates the amount of glutamate released by your body. Cycling NAC prevents building a tolerance, which can have effects on your mood like an inability to feel pleasure whereas cycling caffeine can keep you from developing a dependency on it.
You might find that taking your nootropic five days a week and resting for two days works for you. Taking it for three months straight, then stopping for one month, may be better for others. Many nootropics that suggest you cycle have recommendations on how to plan your weeks, but ultimately, deciding the right routine is up to you and how you feel while taking the nootropic.
Who should (and shouldnt) try a nootropic?
Most of us can understand a desire to be smarter. Many of us have struggled through brain fog and confusion after several nights of staying up too late. A nootropic sounds like something we could all use, but some populations would benefit more from adding it to their routine, and others should stay away at all costs.
Pregnant people, nursing parents, and children under 18 should all avoid taking standard nootropic supplements. There are a few nootropic supplements specifically designed for children (including types from Focus Factor and BrainMD), but we dont know enough about how they might interact with a developing fetus to state theyre safe for pregnant people.
We always strongly recommend sitting down with your doctor before starting any new supplements, especially nootropics. Your situation may be unique, and theyll have the best sense of what might work for you. They may also order lab tests to ensure you dont have any deficiencies, disorders, or other health problems that could be causing your cognitive symptoms.
Psychiatric and neurological medications can cause some of the biggest problems when combined with nootropics. (Well explore this in more depth shortly.) You should also avoid nootropic supplements if youre taking:
- Blood thinners like warfarin
- Levodopa (L-Dopa)
- Cholinesterase inhibitors like Aricept or Reminyl
- Insulin or diabetes medication
- Immunosuppressant medications
Likewise, several conditions can be exacerbated by nootropic supplements. Not every nootropic will affect all of these conditions, but if you have anything listed below, be particularly cautious about starting a nootropic.
- Kidney disease
- Liver disease
- Thyroid disorders
- Heart problems (especially if you have bradycardia, a slow heart rate)
- Ulcers
- Lung conditions like asthma and COPD
- GI blockages or stomach ulcers
- Urinary tract blockages
- High blood pressure
- Endocrine disorders (such as diabetes, thyroid problems, or low testosterone)
- Cancer
- Phenylketonuria (PKU)
- Muscular dystrophy
Nootropics also dont interact well with drugs or alcohol. Some nootropics may be safe to have alcohol in moderation (such as a glass of wine with dinner) while taking it, but its generally best not to combine the two for your livers sake. Ingredients like green tea extract can cause liver inflammation, which is exacerbated by alcohol.39 Recreational drugs generally increase either dopamine, serotonin, or glutamate (inhibiting GABA), so adding nootropic ingredients that do the same thing can lead to side effects like tremors or worse.
Studies on individual products such as the self-funded study on Mind Lab Pro regularly find that nootropics work best for the over-30 crowd. This doesnt mean that they cant help college students or young professionals, but because your 20s are generally some of your healthiest years, theres less age-related dysfunction for the nootropics to address. One of our 25-year-old testers who tried Thesis, for example, found that it supported their focus and clear thinking as much as if not more than a 37-year-old peer tester. Like all other factors, age can make a difference, but your youth alone wont keep you from getting something out of a nootropic supplement.
Psychiatric and neurological conditions
If you have a psychiatric condition even mild depression or generalized anxiety disorder you are more likely to experience negative side effects or worsening symptoms by taking a nootropic. This is especially true if you take neurological or psychiatric medications, which act on the same neurotransmitters as nootropics. Having too much of any neurotransmitters is just as bad as not having enough and can lead to unpleasant side effects like headaches, stomach aches, tremors, or serious complications like serotonin syndrome.40
Serotonin
This neurotransmitter is responsible for our mood, sleep, and digestion, and it stabilizes other neurotransmitters. Its implicated in many psychiatric disorders, most notably depression, and is the subject of many psychiatric mediations. This includes SSRIs (such as Zoloft, Prozac, Celexa, and Paxil), SNRIs (such as Effexor and Savella), MAOIs, tricyclic antidepressants, and some mood stabilizers like lithium. Nootropic ingredients that affect it include acetyl-L-carnitine, Bacopa monnieri extract, L-tryptophan, and Zembrin (Sceletium tortuosum).
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Dopamine
Dopamine plays two roles in our brains: motor movement and reward. Its responsible for pleasure and plays a critical role in our executive functioning.41 Theres a huge range of medications that influence dopamine: stimulants like Adderall, Ritalin, and Concerta; medication for Parkinsons disease like Mirapex; antipsychotic medication (which primarily targets dopamine but may also affect serotonin) like Seroquel, Risperdal, and Abilify; and prescription nootropics like L-dopa and modafinil. Many ingredients in nootropic supplements also affect your dopamine system, including Bacopa monnieri extract, citicoline, L-theanine, L-tyrosine, pyrroloquinoline quinone (PQQ), and uridine.
Acetylcholine
Like dopamine, acetylcholine controls our muscles and learning, memory, and attention. Cholinesterase inhibitors prescribed for dementia or mild Alzheimers disease keep acetylcholine in a neuronal synapse, as do medications treating myasthenia gravis and many eye conditions.42 Acetylcholine-influencing compounds are extremely common in nootropic supplements. The most common ingredients youll find are alpha-GPC, citicoline, and huperzine A, but you might also find DMAE, donepezil, and galantamine.
Glutamate
Glutamate is the primary excitatory neurotransmitter, which makes it easier for neurons to send impulses where they need to go. This speed also means its critical for learning and memory. While there arent currently many prescription medications that directly affect glutamate, there are several companies investigating its potential for treating severe treatment-resistant depression, substance abuse, and obsessive-compulsive disorder. Ketamine, a dissociative anesthetic, works along the glutamate pathway and has shown promise as a potential treatment for severe depression in small doses. In nootropic supplements, caffeine, cocoa, theobromine, and l-theanine may influence glutamate.
Gamma-aminobutyric acid (GABA)
GABA is the primary inhibitory neurotransmitter, turning down the rate of electrical impulses in the brain. Antiepileptic medications, like Lamictal and valproic acid, raise GABA levels. So can traditional anti-anxiety medications like benzodiazepines (Xanax and Klonopin) and barbiturates (Seconal), Gabapentin, and some sedative-hypnotic sleep medications like Ambien. L-theanine can influence GABA, as can phenibut and kratom, but youre more likely to see GABA on its own as an ingredient in nootropics or on its own as a supplement.
Thesis
Best overall, best for brain health, best for stress and anxiety, and best for studying
Pros
Six formulas with unique effects
Available with or without stimulants
Useful starter pack lets you try up to four formulas at once
Wellness coaching included
Outstanding customer support
Free shipping every time
Use code INNERBODY for 10% off your first order
Cons
On the more expensive side
Money-back guarantee is only 30 days
Between strong testing measures and even more robust customer service along with convenient packets delineating daily doses that are easy to travel with - Thesis easily ranks as one of our favorite nootropic companies and is our top pick among nootropic supplements in . The company relies on strong science to back its empathetic messaging, emphasizing that having cognitive deficits isnt a cause for shame but that there are ways to improve your brain in a healthy way.
The company offers six different formulas, posed as working well in pairs. These include:
- Clarity and Logic
- Energy and Motivation
- Creativity and Confidence
Generally, each product contains fewer than 10 ingredients, including caffeine and L-theanine. (You can read more about the individual ingredient breakdowns in our full review of Thesis.) However, there are clear goals for each formula:
- Clarity: increasing blood flow to the brain and stimulating acetylcholine, cutting brain fog
- Logic: improving communication throughout the central nervous system and cell membrane quality
- Energy: boosting cellular energy and blocking adenosine
- Motivation: increasing blood flow to the brain and boosting cellular energy
- Creativity: anti-anxiety and antidepressant
- Confidence: anti-anxiety and boosting dopamine levels
Our testers found that Clarity gave them the biggest effects, with a significant boost to their focus great for a several-hour study session, but some experienced a sense of dissociation or a headache as it wore off. One tester ultimately preferred Logic for a subtler, longer-term sense of clarity and better memory recall.
If you arent sure where to start, you can take a short quiz on Thesis website to determine which one would be best for you. Most quiz results offer more than one formula in the form of a starter kit. This kit allows you to try each blend for a week to see how they affect you, eventually choosing one (or more) to become your daily nootropic. You can also continue to receive the starter kit on a subscription basis and use different nootropics for different situations.
Insider Tip: If you already know what you want to try, you can skip the quiz by navigating to the Starter Kit page. The first question in the FAQ, halfway down the page, has a link to Get Started, where you can assemble your kit yourself.
Special Offer from Thesis: 10% OFF your first order with code INNERBODY
Quite possibly the best part of using Thesis is that you can easily toggle caffeine on or off with any formula. Other companies either dont offer a stimulant-free option or have a different formula that may not be as effective. Thesis simply lets you order any of their formulas without stimulant ingredients included. Our testers did find that caffeine enhanced the effects, so if you arent sensitive to caffeine or are looking for the biggest boost, we still recommend going with the caffeinated form. Plus, if you decide later that you dont want to take caffeine, Thesis keeps each caffeine pill as a separate capsule (the smallest white capsule in each packet), so you can easily ditch it.
Thesis also provides wellness coaching to all subscribers, so you can get the most out of your nootropics and find new ways to improve your life and your brain.
Several companies in this guide take pains to test their products, looking at purity and dosage in particular. But Thesis is among the few who rely on third-party testing rather than internal testing. One of the reasons the ingredient lists in Thesis nootropics are shorter than some of the competition is that Thesis only uses ingredients that are either Generally Recognized As Safe by the FDA or have undergone phase III clinical trials. The only ingredient thats of any potential concern is ashwagandha, which isnt safe for people who have thyroid problems.
Pricing and payments
Thesis has a particularly unique structure. If its your first time ordering from them, youll have to take a quiz to identify what formulas might fit your needs best. Since nootropics can be such a dense, confusing industry to navigate, its a definite plus that Thesis helps you select what might work best for you based on real cognitive testing measures and lets you try more than one formula at once (since a test can only reveal so much). Those are two big benefits you wont find with any other nootropic.
Whether you stick with the starter kit or customize your order, the prices for a 28-day supply remain the same:
- One-time purchase: $119
- Monthly subscription: $79
Subscription orders ship every 30 days, and you cant change their frequency, but you can pause or cancel at any time.
Insider Tip: We recommend you consider starting a subscription for the $30 discount; you can cancel, pause, or skip shipments at any point without hassle, though there are a few more steps involved than other subscription canceling menus. Luckily, you wont have to pay for shipping at any step unless you need a refund.
If you arent happy with your Thesis nootropics, you can reach out to the companys customer service team. Theyll recommend adjustments to a schedule or suggest other products to try first. When you know you want a refund, youll need to go to the returns page, which sends you an link to actually process a return. You can send back any unopened box of Thesis for a full refund within seven days of delivery if you have more than you need, or you can refund one months supply within 30 days of purchase. Youll have to physically mail back whatever you have even if the box is empty and Thesis doesnt cover the cost of return shipping.
Mind Lab Pro
Best for memory and best non-stimulant
Pros
Supported by independent research
Stimulant-free
Vegan formula
Flexible dosing options
Uniquely socially conscious among nootropics
- Free bottle with a purchase of three
Cons
Limited ingredient dosages
Free shipping on the largest orders only
Complicated return policy
No subscription options
Mind Lab Pro has a lot going for it, including third-party testing and research. Its study is the most successful self-funded study out of any nootropic on our list, displaying the best results after three months of taking Mind Lab Pro in the following areas:
- Simple choice and reaction time
- Anticipation (predicting the next step in a structure)
- Information processing (especially for people 30+)
- Immediate and direct recall (memory)
The supplement doesnt use any novel ingredients, and its components all boast research of their own that show safety and efficacy. These include citicoline, lions mane mushrooms, and Rhodiola rosea, among others. Notably, though, all but three (two B vitamins and lions mane) are all underdosed compared to the supportive outside research. Luckily, Mind Lab Pros study is so successful that its still very likely youll see positive results from this nootropic.
They also have one of the lowest allergen profiles of any nootropic, as their formula is:
- Gluten-free
- Soy-free
- Nut-free
- Synthetic additive-free
- Caffeine-free
- Non-irradiated
- Vegan-friendly
We think this is your best option if you want a generalized nootropic and know you dont want a caffeinated supplement. You can learn more about its ingredient profile and how its changed over time in our full review.
Because Mind Lab Pro only offers one product, the pricing structure is simple:
- One Bottle: $69
- Two Bottles: $138
- Three Bottles (plus one free): $207
Shipping on three-bottle orders is free, but smaller orders incur a charge of $9.95 for standard (3- to 10-day) or $14.95 for expedited (2- to 4-day) shipping. Mind Lab Pro has also kept in mind that mail times have slowed substantially in the last few years, extending their delivery windows by a few days.
Their refund policy is confusing, depending on whether you just want a refund or want to use their money-back guarantee.
You can get a refund in full within 14 days of delivery, assuming you havent opened the bottle. The money-back guarantee only applies to the first bottle in your first order, but you can claim a refund through this policy within 60 days, and youll have to pay shipping both ways. This reduces your expected refund amount to about $40.
TruBrain
Easiest to take
Pros
Several delivery methods into the body
Various bundles available
Great for people who cant swallow pills
Shots are extremely convenient
Specific supplement for brain aging
Free shipping
Cons
No money-back guarantee
Contains full-spectrum CBD oil
Drinks contain high-FODMAP ingredients
Designed by UCLA-trained neuroscientists, TruBrain offers a novel delivery method for their most popular nootropics. Each product is available in liquid form and stored in a small pouch. You can crack one open and drink it in short order, and it doesnt matter if you have any trouble swallowing pills.
There are seven available flavors:
- Sleep: uses GABA, melatonin, and 5-HTP to relax you
- Mellow: an all-around balanced and low-dose nootropic with Noopept, vitamin C, NALT, centrophenoxine, magnesium, L-theanine, and CBD oil
- Matcha: a green-tea-based drink with magnesium, Noopept, and NALT designed to increase mental clarity
- Mushrooms: a botanical blend with four mushrooms and vitamin C intended to promote cognitive health
- Medium: identical to Mellow, but without the CBD oil
- Strong: a caffeinated version of Medium
- Extra Strong: Strong plus 150mg of Adrafinil, a non-prescription version of modafinil
Mellow, Medium, and Strong are all nearly identical; Mellow adds functional CBD oils, and Strong adds caffeine. While theyre easy to take, youll need to be careful if you cant take CBD or regularly need drug testing since full-spectrum CBD oil does contain a small amount of THC. (Though not enough to provide any psychoactive effects, the full-spectrum CBD oil in TruBrain could potentially cause you to fail a drug test.) Overall, the doses are okay, and TruBrain picked somewhat unconventional ranges of ingredients; Noopept is a strong, branded nootropic with some more serious side effects than normal, but theres little research supporting most of the mushrooms included in the Mushrooms flavor despite not having any major known side effects.
Customers generally report that the flavors are pleasant, though there are a significant number of other ingredients added to make these drinks palatable. Overall, we think that TruBrains unique form makes their drinks interesting and a good option for people who dont like taking pills, but they dont offer as much value on a supplemental level as something like Thesis, which has many similar customizable aspects, starter kits, and trials and more advantageous formulas.
If you arent crazy about the thought of drinking your nootropic, TruBrain has shifted its capsule offerings to encapsulate all seven formulas (pun intended) as TruBrain Capsules. Now, you can get one bottle of 30 servings in every formula for the same flat price, which varies depending on how youre ordering it. This payment structure is almost identical to Qualia Minds, though youll get a much more succinct ingredient list and a few more servings for $10 more on your first order.
You can get these drinks with both bulk (from 10 to 60 pouches per order) and subscription deals (10% off every delivery). Uniquely, you can also prepay and save up to a year in advance for 30% savings if you know you like them and will continue to drink these supplements through the subscription program. You can choose exactly how many of which flavors you want, which is a nice bonus.
One-time costSubscription cost (first order)Subscription cost (second and beyond)Drinks (10)$39$35$35Drinks (15)$55$49$49Drinks (20)$65$59$59Drinks (30)$79$69$69Drinks (60)$145$129$129Capsules$139$69$119If you live in the U.S., you can also try 10 drinks for $29 with free shipping, though you wont be able to pick and choose exactly how many of each flavor youll get. Note, though, that it automatically signs you up for a 20-drink monthly subscription; if you dont cancel within two weeks, youll be charged $59/month for a box of 20 TruBrain drinks.
Clockwise
Clockwise is TruBrains brain aging supplement designed to counter the effects of time on cognition and memory. It contains nicotinamide, a B vitamin that can increase NAD production and mitochondrial functioning. That improved mitochondrial function should be able to address multiple systems, not just the brain.
Clockwise also contains green tea extract, vitamin C, and alpha-lipoic acid, among other ingredients in smaller quantities. However, note that these capsules are on the larger side, so they arent as accessible for people who have trouble swallowing. In that case, stick with TruBrains custom drinks.
One bottle of Clockwise costs $69, or you can subscribe and get bottles for $65 per month. (Those prices have gone up $4 and $6, respectively, in the last year.)
Powder Sticks
Unlike the shots, which are premixed, TruBrains powder sticks are designed for you to mix with water or a beverage of your choice. They contain Noopept, a generous dose of vitamin C, and several other nootropic ingredients. TruBrain uses xylitol, monk fruit, and stevia as sweeteners, so theres no added sugar.
TruBrain Powder Sticks can make a good substitute for a mid-day cup of coffee. Each one contains 100mg of caffeine.
TruBrain Powder Sticks cost $59 for a one-month supply, or $55 per month if you subscribe.
TruBrain Bars
These bars are one of the few solid, edible delivery methods for nootropics. They contain Noopept, citicoline, and theanine, along with several sources of healthy fats like chia and flax seeds. Their macronutrient balance isnt the best among protein or meal replacement bars, but these really belong to a different class than those.
TruBrain Bars currently come in just one flavor: triple cacao. Theyre primarily sweetened with dates but also contain stevia.
You can get a box of 12 or 24 from TruBrain, and heres how they price out:
- Box of 12: $55/box or $49/box with a subscription
- Box of 24: $99/box or $89/box with a subscription
Other TruBrain products
In addition to their signature shots, TruBrain offers a handful of other products, some of which are nootropics. (Others include ketogenic powder, coffee, and protein bars, all designed with brain health in mind.) TruBrain has a prepay and save system on select products that allows you to save up to 30% when you buy in bulk. Heres how it breaks down:
- 3-month supply: 10% off
- 6-month supply: 20% off
- 12-month supply: 30% off
You can get free shipping on any order that costs more than $55. TruBrains return policy is quite strict and will only accept a return if you send back an unopened box within seven days of delivery (not just the products themselves, but the container theyre delivered in). You also wont be refunded the cost of shipping.
Focus Factor
Best budget pick
Pros
Extremely inexpensive
Almost all formulas are uncaffeinated
Extensive ingredients list
One of two companies to make a kids formula
Gummies and drinks available
Comes with its own companion app
Cons
No returns
Some formulas are particularly unsafe for pregnant people
Unclear nootropic dosage
Some ingredients lack long-term safety data
No safety and testing information available
Focus Factor has its hands in several different areas of your cognitive health, branded and packaged specifically to help you while also providing things like energy drinks and partnering with NASCAR. Their Original formula includes a litany of ingredients connected with higher brain function. Some of these include:
- DMAE
- L-Glutamine
- Bacopa monnieri extract
- Phosphatidylserine
- Inositol
- NALT
- GABA
- Vinpocetine
- Electrolyte concentrate
- Huperzine A
- Choline
- Iodine
- Zinc
- Selenium
- Magnesium
- Molybdenum
- More than a dozen vitamins
Focus Factor provides a dose for their proprietary blend of nootropics, but they dont reveal the quantities of individual ingredients in their blend. They do have specific measurements for each of their vitamins and minerals because its required by law, but everything else hides under the blend label. And that blend is relatively small, too Focus Factor Original contains only 640mg of the entire blend, whereas most successful studies use that much on one ingredient alone.
A self-funded study found moderate success, improving participants scores on a verbal learning test over six weeks with no complaints of serious side effects. However, because it has huperzine A (albeit in a likely very low dose), you may find you need to cycle this nootropic.
One important ingredient is vinpocetine, which is present in Focus Factor Original. Vinpocetine is a known teratogen, meaning it might cause birth defects and miscarriages if someone consumes it regularly or in a high enough dose while pregnant. Nootropics arent generally a good thing to take while pregnant or lactating, but you should especially stay away from Focus Factor for your babys health. Theres no clear information on Focus Factors website about the products safety, nor any information about in-house or third-party testing, and asking customer service doesnt provide any new knowledge, either.
Ultimately, if youre already taking a multivitamin, you likely wont get anything new out of Focus Factor. However, if your general nutrition needs a boost or if youre hesitant to try a potent nootropic, Focus Factor Original could be a good fit. We dont recommend any of Focus Factors other products, aside from their childrens line and Focus Factor Brain & Vision, because there just arent enough differences to justify their increased costs.
And in the case of the companys energy shots, theyre identical to 5 Hour Energy and Monster drinks, which are significantly more accessible from your nearest gas station or vending machine, whereas Focus Factor isnt sold in stores.
You can learn more about Focus Factor including a full product breakdown in our review.
Pricing
Heres a look at the companys lineup and costs, which come down with larger orders:
Price per bottleLowest possible priceNootropic blend doseOriginal (60-count)$14.99$mgExtra Strength (120-count)$39.99$38.mgMax Strength (120-count)$59.99$53.mgBrain & Vision (120-count)$39.99$38.mgGummies (60-count)$29.99$26.mgKids Chewables (150-count)$24.99$.5mgKids Extra Strength (120-count)$29.99$mgThe Focus Factor Kids formula is extremely mild compared to the adult-oriented formula. We think this is a good thing, as childrens brains are still developing and are more susceptible to potential side effects.
The childrens formula includes the following in their nootropic blend:
- Bilberry (fruit)
- N-Acetyl L-Tyrosine
- Inositol
- Coenzyme Q10
The company has also added a new line of nootropic products in the last year, which are designed to work better for gamers. However, we still prefer their Original and Brain & Vision formulas; the nootropic formulas are closer to pre-workout and energy drinks than true nootropic supplements.
In the last year, Focus Factor has added free shipping to U.S. addresses for orders of $50 or more. If you dont meet that $50 threshold, shipping from Focus Factor costs the following:
- Standard (5-7 days): $6.95
- Priority Mail (1-3 days): $14.95
Focus Factor doesnt accept any returns unless your product arrives defective.
Brain Hub
One of the coolest things that Focus Factor offers is the Brain Hub app. You can try it for free for seven days, and it provides you with guided meditations, a small audiobook library, mind and mood trackers, and a suite of five kinds of brain games (in focus, memory, math, problem-solving, and language) designed to keep you sharp and show how youre progressing as you take their supplements. However, our testers only found two game categories actually fun (focus and problem-solving).
The app looks old and isnt super intuitive, and we think there are better cognitive training apps on the market, but because this one is paired with Focus Factor and comes with a free trial, its worth it to give it a shot. Just be sure to cancel as soon as you can so you dont accidentally get charged.
After your week-long free trial, you can pay for the Brain Hub app in the following ways:
- Monthly plan - $17.49/month
- Yearly plan - $59.99/year (saves you $149.89)
- Lifetime plan - $299.99 billed only once
BrainMD
Best range of products
Pros
Huge range of nootropic supplements
Supplements have a targeted focus
Quiz is useful and not overly prescriptive
Can shop by dietary restrictions
Good learning resources
Cons
Too many nuanced options for some users
Generalized nootropics are very expensive
Some supplements use up to 10 capsules per serving
BrainMD offers both comprehensive nootropics like Brain & Body Power and more targeted combinations like Calm My Brain. The latter supplement provides only magnesium and ashwagandha, whereas Brain & Body Power boasts more than 40 ingredients. Generally speaking, products with shorter ingredient lists tend to be higher in quality with doses more in line with scientific research than products like Brain & Body Power that contain dozens of ingredients. The companys more targeted supplements tend to deliver higher doses of specific ingredients, and their more comprehensive offerings have relatively low doses of each component. Its a great brand if you know youll want to shop around and try a few different kinds of supplements for your cognitive health.
It can be difficult to know which of the companys vast array of products you should take, so they offer a short quiz about your lifestyle and cognitive performance. After the quiz, an algorithm will identify yours as one of 16 brain types. The site then lets you shop by your brain type to see only the supplements that would provide you with the biggest potential benefit. Its more comprehensive and less prescriptive than Thesis quiz, which is better for people who want a more hands-on approach to their supplement journey.
BrainMDs prices vary widely depending on their ingredient lists (as do the products efficacy). Subscribing is a good way to save, as youll take 15% off your order, but the companys supplements are a bit expensive for what they offer. They arent as high-priced as TruBrains Clockwise or Qualia Mind, but they also dont generally have the same first-time saving discounts. Instead, you can bundle both subscription and bulk deals for extra savings, like Focus Factor.
Heres a look at a few of their most popular supplements:
One-time purchaseCost per bottle (1) if you subscribeCost per bottle (3) if you subscribeCost per bottle (6) if you subscribeBrain & Body Power$104.95$89.21$83.96$78.71Serotonin Mood Support$52.50$44.63$42$39.38Focus & Energy$41.95$35.66$33.56$31.46Happy Saffron Plus$51.45$43.73$41.16$38.59Brain & Memory Power Boost$62.95$53.51$50.36$47.21Put Me To Sleep Naturally Chewables$41.95$35.66$33.56$31.46Neuro-C Vitamin C liquid$46.95$39.91N/AN/APreviously, all seven of these supplements were available as part of a free trial program. Now, they only offer Put Me To Sleep Naturally, Happy Saffron Plus (which is one of our top picks for the best saffron supplement), Brain & Body Power, and Serotonin Mood Support, but you can still try any one of them for free for up to 14 days. After that, BrainMD will automatically enroll you in a subscription program for that supplement at the products standard cost.
Shipping with any subscription order is free, and non-subscription orders cost a flat $7.95 unless you order at least $75.
Hunter Focus
Pros
Well-designed nootropic ingredient combination
Free shipping on bulk orders
Buy three bottles, get one free
Part of a three-supplement plan
Cons
Large serving size (six capsules)
No subscription options
Hunter Focus is the nootropic component of Hunters supplement system. Much like Onnits range of products, the companys system includes Hunter Burn, a thermogenic fat burner, and Hunter Test, a natural testosterone booster.
Hunter Focus is a relatively straightforward supplement. It contains many of the most popular nootropic ingredients in relatively high doses. Heres a brief look at some of their most effective ingredients:
- Acetyl-L-Carnitine (800mg)
- L-Tyrosine (500mg)
- Lions mane (500mg)
- Bacopa (300mg)
- Ashwagandha (300mg)
- Citicoline (300mg)
- Maritime pine bark extract (75mg)
All told, Hunter Focus contains 20 active ingredients that can directly or indirectly improve cognition, memory, and mood. This nootropic is very similar to Mind Lab Pro but contains more ingredients at slightly higher doses. Some of these ingredients are likely to bring positive benefits ashwagandha root and ginseng, for example while others are still on the newer side in research, such as Spanish sage. Hunter Focus contains 100mg of caffeine, so its not a good option for people who want a stimulant-free nootropic. (100mg is about what youll get in a cup of coffee and is very typical to find in nootropics that have caffeine.)
Between the two, we think Mind Lab Pro will be better for more people because some of Hunter Focus ingredients may inadvertently cancel each other out or cause strange side effects. Combining ashwagandha and caffeine may cause a particularly complicated response, for example. However, theres nothing that stands out as harmful or otherwise strange in this supplement, so it is still a solid option.
Hunter Focus doesnt offer any subscriptions, but you can save a little bit by buying in bulk (though comparatively much less than other products that offer bulk savings). Heres how Hunter Focus pricing works out:
- One bottle: $90
- Two bottles: $180
- Three bottles (plus one free): $270
Youll get free shipping as long as you buy two or more bottles at a time. Shipping for one bottle costs $7.95. Hunter has some of the widest-reaching international shipping options available with depots in London and Tennessee, and they can ship to all but 17 countries. If you dont like Hunter Focus, you can return your bottle, opened or unopened, within 30 days of delivery; just reach out to their customer service team with your name, , and order number, and tell them youd like to return your bottle of Hunter Focus (and why) to get the ball rolling.
Qualia Mind
Pros
Transparent formulation
Large B vitamin doses
Contains several well-regarded ingredients
Steep discount on first subscription delivery
100-day money-back guarantee
Non-stimulant option available
Cons
Particularly expensive
Most ingredients are underdosed
Several ingredients lack clinical backing
Take seven capsules daily for a full dose
Qualia Mind is the nootropic offering from a company called Neurohacker Collective. They make other supplements to support skin, sleep, energy levels, longevity, and vision. Mind is their standard nootropic blend with both common ingredients and some more unique choices. There are 27 different ingredients in Qualia Mind, so youll have to take seven capsules to get a full serving.
These ingredients include:
Vitamin C
Vitamin D
Thiamine
Niacin
Vitamin B6
Vitamin B12
Pantothenic acid
Acetyl-L-Carnitine HCL
Artichoke leaf extract
Bacopa monnieri extract
Rhodiola rosea extract
DL-Phenylalanine
NALT
Taurine
L-Theanine
Alpha-GPC
Uridine-5-monophosphate
Citicoline
Whole coffee fruit extract
Velvet bean seed extract
Phosphatidylserine
Vegan DHA
Celastrus paniculatus seed extract
Ginkgo biloba leaf extract
Coleus forskohlii root extract
Pyrroloquinoline quinone
Huperzia serrata
Its also important to note that Qualia Mind is generally underdosed in these ingredients compared to clinical studies. You could make the argument that we dont know if the ingredients can all boost each other to sufficient efficacy, but wed have to turn to the self-funded study on Qualia Mind to determine that. This study was thorough and clinically run, but after measuring six major cognitive performance aspects (executive function, attention and focus, inspiration, perceived stress, work engagement, and mindfulness) as well as self-reported sleep quality, immune health, productivity, and mood, researchers found that there was little difference between Qualia Mind and a placebo.
While its a relatively safe and very well-tested supplement, Qualia Mind isnt going to be the best option for someone whos just getting started with nootropics. If you dont mind taking a lot of pills and are looking for a generalized nootropic with focus- and attention-boosting potential but are sensitive to high ingredient doses, Qualia Mind may be a good fit for you.
Learn more about Qualia Minds ingredients in depth in our full review.
Pricing
Neurohacker Collective offers steep sales on all products when you start a subscription program. You can save $100 by ordering Qualia Mind as a subscription once and then canceling your subscription rather than purchasing a single bottle one time.
Heres a closer look at Neurohacker Collectives nootropic lineup:
One bottleFirst bottle of subscriptionSubscription cost after thatQualia Mind$139$39$119Qualia Mind Caffeine Free$139$39$119Qualia Focus$49$24.50$39.95Qualia Mind Energy Shot$139$69.50$119The company used to offer free shipping on most orders but now charges either $7.98 for standard shipping (3-5 days) or $12.98 for priority shipping (2-3 days), only to a restricted list of English-speaking countries. Or, if you order from a third party, youre more likely to get a now-extinct product called Qualia Mind Essentials, which comes in smaller sizes and has a shorter ingredient list. For the greatest chance of effectiveness, we recommend purchasing from the Neurohacker Collective website specifically.
Neurohacker Collective has one of the longest money-back guarantees in its category, offering users 100 days to see if the product works (and youll still get a refund if you open the bottle and test it). But a closer look reveals downsides here:
- The refund will only apply to your initial order or the most recent order within a subscription. You could start a subscription and ask for a refund on day 99, but youll only get a refund for whatever was part of that last months order.
- Your entire household will only be eligible once. This means you wont be able to access a refund if someone in your household happened to try Qualia Mind in the past and returned it.
Onnit Alpha BRAIN
Pros
Company has a focus on fitness
Liquid nootropic shots available
90-day money-back guarantee
Military discount available
Cons
Limited dosage information
Free shipping only on orders over $150
Onnit is a full-scale fitness brand offering everything from nutritional supplements to workout equipment. They have four Alpha BRAIN nootropic products that are caffeine-, dairy-, nut-, and gluten-free, as well as more than two dozen other supplements designed to optimize your health and wellness. Well focus mostly on their flagship product, Alpha BRAIN capsules, which also come in a Black Label version (with clearer dosage information, albeit a dissimilar ingredient list), an Instant powder, and Focus Shots, which are premixed caffeine shots with other nootropic ingredients.
Alpha BRAIN has a decent ingredient list as far as nootropics go, with a big focus on boosting your acetylcholine levels as much as possible (which may lead to things like intense lucid dreaming. and requires a strict cycling routine).57 However, most of these ingredients are hidden behind a few proprietary blends, meaning Onnit provides the measurement of blend per serving but not each individual ingredient. While its used to keep competitors from copying an exact formula, it also keeps you from understanding what youre actually taking. Onnit does well with testing measures, but the lack of greater transparency is a disappointment for Alpha BRAINs overall safety measures. Proprietary blends make it difficult to determine what side effects youll be more likely to experience, if any. And while proprietary blends are sadly not uncommon in nootropics (and Alpha BRAIN isnt the worst offender, at least breaking down their blend into three separate smaller blends), it isnt something that gives us confidence.
Alpha BRAIN has been subject to two scientific studies with mixed results, though they both found some evidence that Alpha BRAIN improved verbal memory scores. If youre looking to improve learning and memory overall with a special focus on being able to restate what you know and are able to track a cycling schedule, this might be a good option for you.
You can learn more about Alpha BRAIN and its specific ingredient breakdown in our full review.
Alpha BRAIN pricing
Onnit Alpha BRAIN supplements come in various quantities, with larger orders offering impressive savings. Heres a look at how their four nootropics price out:
PricePrice with subscriptionBulk deals?Alpha BRAIN 30-count$34.95$29.71Alpha BRAIN 90-count$79.95$67.96Black Label 80-count$124.95$106.21Instant 30-count$59.95$50.96Focus Shots 6-count$23.99$20.39Focus Shots 24-count$76.77$65.25A 30-count bottle of Alpha BRAIN is the only option where you can get a bulk discount. If you buy two bottles, youll save 25% ($26.22/bottle, or $52.43 total), and if you order three bottles, youll save 30% ($24.47/bottle, or $73.40 total). Both bulk deals give you a free copy of Joe Rogans seven-page eBook on his life philosophy and workout routine, but you shouldnt let the free gift sway you you can find the PDF for free elsewhere on the Onnit site.
You can also get a 15% discount as a member of the military, first responder, or medical provider, though youll need to verify your identity at checkout with an ID the first time you want to use this discount.
Shipping from Onnit is free on orders over $150. Otherwise, shipping varies depending on your location; our testers found it averaged between $7 and $11.
If you know where to look, you can also get a free trial of Alpha BRAIN. Onnit will give you a 30-count bottle of Alpha BRAIN for just the cost of shipping and sales tax, though its slightly hidden on Alpha BRAINs webpage. Onnit also features the second-best return policy on our list with an extra twist you have 90 days to return any bottles that are at least half-full for a full refund. If you ordered a 30-count bottle for your first purchase and didnt love it, Onnit will give you a full refund for the bottle without asking you to return it within that same 90-day window.
Alternatives to nootropic supplements
Your brain is the control center of the rest of your body, but theres a two-way connection. What you eat, how you sleep, and hundreds of other small decisions influence how well your brain works. Not every factor is something you can control as much as we might like to, theres no stopping aging but there are still plenty of things you can control. Improving other areas of your health will also often improve your daily cognitive functioning.
Generally, we first recommend checking in on your daily habits (are you sleeping and eating enough? Are you getting time outside?) and making lifestyle changes if youre otherwise healthy. Adding supplements like vitamins, minerals, and individual nootropic ingredients is also a good bet if youre struggling without an identifiable cause especially B and D vitamins, omega-3s, and ashwagandha. And if things dont get better with nootropics, lifestyle changes, and other vitamins, we encourage you to reach out to your doctor. There may be a more serious underlying cause, and theyll be able to point you in the right direction.
Supplements
Many of the individual ingredients in nootropics can be purchased on their own as supplements, like ashwagandha, ginseng, vitamins, and minerals, if youre curious about how a particular supplement works but dont want to commit to the full ingredient roster (or price) of a nootropic supplement. However, there are a few other kinds of supplements that improve common complaints also addressed by nootropics.
Energy
Fatigue can be hugely detrimental to your cognition, making it more difficult to think, recall memories, and convey ideas, and can dampen even great moods. Its also a common symptom of multiple kinds of vitamin deficiencies most notably vitamins B and D so simply taking a vitamin (or multivitamin) supplement for energy can improve your cognition without having to turn to nootropics. (If you still want to try a nootropic but feel like a multivitamin may help you more, try Focus Factor Original.) Otherwise, vitamin supplements are cheaper and safer than nootropics. If a multivitamin isnt the right step, you can also try a pre-workout supplement, which is designed for muscle building and exercise expansion, rich with amino acids and caffeine; theyre generally safer but less convenient to take, and they may not do much for you if you arent working out while youre taking them.
An aging brain
Omega-3 found in things like fish oil, algae, and walnuts is one of the best things you can take for your brain as you get older. One large study in late found that even among people in their 40s, omega-3 intake correlated almost directly with brain health and structure, altered slightly by APOE genotype.43 Omega-3 supplements are generally inexpensive and high-quality, as theyve been around for a significant amount of time and are highly popular. If you arent thrilled about the possibility of dealing with fishy burps, NAD+ supplements improve mitochondrial functioning that wanes with age. Since NAD+ is closely linked to vitamin B3, these supplements are generally safer than the botanical blends in nootropics, though they arent necessarily less expensive, depending on the brand you choose. (We recommend Renue by Sciences NMN SL sublingual powder, which is easy to take and only about $32.)
However, we recommend not using Prevagen, another nootropic supplement advertised as the best for an aging brain. It only contains a small dose of vitamin D and apoaequorin, a protein found in bioluminescent jellyfish that binds to calcium, which some researchers think may lead to neuronal death in excess. Studies have shown that Prevagen just doesnt really work.44
For anxiety and depression
The best ingredients for anxiety and depression in a nootropic supplement are easy to find on their own. Ashwagandha and ginseng are likely to be your best bets, as they have some of the most reliable clinical backings for stress relief.
You may also find success with a GABA supplement, particularly if you struggle with anxiety. However, if you have low blood pressure, you shouldnt take a GABA supplement. GABA effectively lowers blood pressure, which is situationally great (high anxiety can raise blood pressure, even if you dont have hypertension), but it can be dangerous if your blood pressure is low at the outset. We think Thornes PharmaGABA is the best GABA supplement on the market because of its high efficacy and flexibility. It comes in two doses: 100mg, which will be better for low-level anxiety, and 250mg, which will be better for more moderate anxiety and insomnia.
There arent as many non-prescription options for depression as there are for anxiety, and most of them that do exist have some serious problems. 5-HTP, a precursor to serotonin, is one of the bigger names youll see, but we hesitate to recommend it because 5-HTP can be toxic, causing serotonin syndrome in high doses. Most studies seem to agree that 5-HTP can alleviate depression symptoms, but these studies are also small.
If youre struggling with depression, dont be afraid to reach out to your primary care provider. Most general practitioners will write prescriptions for common SSRI antidepressants like Zoloft, Prozac, and Celexa, so you dont have to wait for a psychiatrist appointment.
Lifestyle changes
We know: this is the last thing you want to hear. But living through the last few years means youve likely picked up some bad habits, experienced extremely high stress levels, or changed your lifestyle completely. Its worth re-examining your daily routine to find ways you can naturally improve factors that impact cognition. These steps may make a bigger difference for some people than others it may be more practical to fix your sleep cycle as a college junior than as a new parent but its always going to be faster, safer, and generally better to try making lifestyle changes first.
Sleep
Getting your eight hours a night is critical for proper brain function. While the exact mechanisms of sleep are still elusive, one theory is that sleep helps wash your brain, and medical experts know that your risk of brain disease increases the more sleep debt you get into. And sleep debt is difficult to recover from even missing just two hours a night during one work-week means youll need to sleep an additional ten hours just to catch back up to baseline. Sleep deprivation is also closely tied to poor mental health outcomes and worse higher-level cognitive abilities.45
Caloric intake
Some people find they experience sharper cognition when they eat fewer calories, closer to their basal metabolic rate. Others find they arent actually eating enough, and eating more improves their capacity. Researchers have found that people suffering from anorexia nervosa who are underweight have diminished sensorimotor speeds and struggle with forgetting long-term memories, which improve with recovery and weight gain.46 Different foods can make an impact on our cognitive states, too; our brains need healthy amounts of carbohydrates, protein, and healthy fats in order to function at full capacity.
Movement
According to a meta-analysis, long sessions of coordinated exercises such as yoga, tai chi, and pilates are the most beneficial for our brains, particularly if youre male.47 The length of time youre exercising is important here, as longer exercise routines require you to practice your planning, concentration, and willpower abilities, which strengthen the brain beyond the other healthy effects of exercise.48 The neural benefits of exercise are even greater for people with mild cognitive impairments, as evidenced by a study that also found lower levels of depression and better sleep quality.49
Going outside
Psychological researchers agree: touching grass really can make a big difference in your mental health. Exposure to natural settings improves participants working memory, cognitive flexibility, and attentional control more than exposure to urban centers, likely due to our long-standing evolutionary ties to natural settings.50 Even things like air pollution and city noise can decrease your focus and general psychological functioning over time.51 Spending a few hours in spaces rich in green whether its your backyard, a forest on a long hike or kayaking down a river can help reset your brain and improve your cognition.
Blue light and screen time
The harmful effects of blue light on our sleep are well established. Sunlight is blue light, and so is the kind that emanates from our screens. Your brain uses blue light to regulate your internal clock; getting too much blue light disrupts your natural melatonin production, making it more difficult to sleep and causing sleep loss, which dramatically affects cognition. Using blue light filters (built into iPhones and with downloadable programs for computers) and wearing blue light glasses can help diminish blue lights effects, but minimizing screen time especially in the two hours before bedtime makes the biggest difference.
Music
Our testers all listen to music regularly while they work and find it makes a big difference in their ability to focus. Studies generally agree: background music improves attention scores, with a few caveats. The best music to listen to if you want to improve your attention is generally low-energy music without lyrics that you already know.52 53 Genre doesnt matter, but anything that you dislike or enjoy too much can be distracting.54 Both scientists and musicians are picking up on this, and new concepts like binaural beats (providing slightly different tones to each ear in stereo) are starting to pop up, but note that familiarity is still one of the most important parts that makes music effective.55
Brain exercises
Focus Factor had the right idea when the company decided to release a cognitive training and diary app alongside supplements. Cognitive training through electronic games has been around as long as the technology it runs on, and many companies make huge claims about what their apps can help with (including things like ADHD, PTSD, Alzheimers, and dementia). However, a meta-analysis looking at almost 8,000 studies found only two brain training programs had more than one study in their favor (BrainHQ and CogniFit), and theres no evidence to support them as a preventative or treatment strategy.56 Ultimately, playing brain games wont make a huge difference in your cognition, but it can help you flex some skills better than another round of Candy Crush.
See a doctor
Whether youre struggling with mild depression or the signs of early dementia, nootropics might help, but they arent a cure. We always recommend talking to a doctor before trying any supplements, especially nootropics, as there may be an underlying cause for your brain fog that needs to be professionally treated.
Depending on your experiences, you may be given:
- Stimulants like Adderall or Ritalin
- Dopaminergic medications like L-Dopa
- Antidepressants like Paxil
- Anti-anxiety medications like Xanax
- Sleep medications like Ambien
It can be difficult to identify the root cause of cognitive issues because its a symptom of hundreds of different conditions, so checking in with a medical professional might help you catch something like hypothyroidism or anemia or, more seriously, something like MS or early-onset Alzheimers. You could also be experiencing a vitamin B12 deficiency, depression, or long COVID. A doctor will be able to look at your particular cognitive struggles and give you tests to identify the specific underlying problem. (Again, a nootropic supplement cannot, and will not ever, give a diagnosis, nor will it cure or prevent medical concerns.)
Nootropics FAQ
No. Like any other supplement, when you stop taking a nootropic, youll stop seeing its effects. This doesnt mean that youll lose access to new memories youve made, but any cognitive benefits youve gained will revert back to how your brain was functioning pre-nootropic. Most studies suggest that it takes 4-6 weeks of consistent use to reach a nootropics full potential. Studies also suggest that the effects slowly wear off over the course of one month after stopping if youve been taking them for at least six weeks. You can always go back on a nootropic after youve stopped taking it, too.
Taking a nootropic doesnt mean youll wake up a genius after a few weeks (or days). Nootropics can help you stay focused and improve your memory recall abilities, which may make studying easier or help you remember what you learned on your latest Wikipedia deep-dive. But youll still have to put in the effort to learn new facts and skills.
Nootropic supplements arent a replacement for prescription medications. As a supplement, its against the FDAs rules to state that they can treat or cure (or diagnose, prevent, or mitigate) any diseases and disorders, including those related to your cognitive health like ADHD or Alzheimers disease, no matter how mild they are. Nootropics may improve aspects of your cognitive performance, and some ingredients show promise in clinical studies by improving the quality of life of people with dementia, but nothing is proven or guaranteed. If youre struggling with your mental health, we strongly recommend reaching out to a psychiatrist or your general physician first.
Not only is it possible, but many people prefer building their own nootropics from individual ingredients. This is called building a stack, or a combination of ingredients much like one youd find in a traditional nootropic supplement. There are pros and cons to this strategy.
On the negative side:
- Youd have to do the research to determine the proper dose.
- This approach sometimes involves swallowing many pills.
- Your safety isnt as guaranteed as it is with a trusted nootropic manufacturer whos done the right testing or formulated its product with proper caution and respect for what clinical studies have shown.
But it does mean you can choose to take only the ingredients that work well for you, which is always a good approach. Since it can be a little tricky to identify what does and doesnt work, we recommend finding single-ingredient supplements from trusted manufacturers like Nootropic Depot through companies like iHerb, where you can order all of your ingredients in one place.
The term nootropic comes from two Greek words: nous, meaning mind or intelligence, and tropikos, meaning turning or changing. (That means that nootropic roughly translates to mind-changing.) Noo- sounds like new, and -tropic would rhyme with toe-pick.
For more information, please visit Citicoline Sodium And Brain Health.
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